Androgen insensitivity syndrome is a condition that affects sexual development before birth and during puberty. Androgen insensitivity syndrome (AIS) is when a person who is genetically male (who has one X and one Y chromosome) is resistant to male hormones (called androgens). This term is actually used to describe many different conditions that are connected to a person's sex organs. Know the causes, symptoms, treatment, diagnosis and epidemiology of Androgen Insensitivity Syndrome. A child born with AIS is genetically male, but the external appearance of their genitals may be female or somewhere between male and female. Note.—AIS = androgen insensitivity syndrome, HCG = human chorionic gonadotropin, SRY = sex-determining region on the Y chromosome, TDF = testis determining factor. The 29-year-old from Chicago has Androgen Insensitivity Syndrome (AIS), a very rare disorder affecting 1 in 20,000 which prevents a womb from growing and causes testes to … As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. Androgen insensitivity syndrome in its complete form is a disorder of hormone resistance characterised by a female phenotype in an individual with an XY karyotype and testes producing age-appropriate normal concentrations of androgens. The second picture is a recent photograph of Angela and Michelle. One of the many conditions that falls under this category is Androgen Insensitivity Syndrome. She was born with androgen insensitivity syndrome, where, despite being genetically male with male chromosomes, the body doesn’t respond to testosterone properly, preventing the … As such, the insensitivity to androgens is only clinically significant when it occurs in individuals with a Y chromosome or, more specifically, an SRY gene. People with this condition are genetically male, with one X chromosome and one Y chromosome in each cell . Causes. Approximately one out of every twenty thousand people have it. Angela has partial androgen insensitivity syndrome (PAIS). The third picture shows Angela and David Cameron, both members of the board of directors of the Intersex Society of North America , a patient advocacy group. According to, this is an incredibly rare condition. In an individual with complete AIS, the body’s cells are unable to respond to androgen, or “male” hormones. Androgen Insensitivity Syndrome, or AIS, is a genetic condition, inherited (except for occasional spontaneous mutations), occurring in approximately 1 in 20,000 individuals. Complete androgen insensitivity syndrome (CAIS) is a condition that results in the complete inability of the cell to respond to androgens. Androgen Insensitivity Syndrome is a syndrome that affects the body of the individuals by making them unable to react to male sex chromosomes known as androgens. RG Volume 28 • Number 7 Chavhan et al 1895 whereas those associated with male and female She has androgen insensitivity syndrome (AIS) which means she has male chromosomes but her body has not responded properly to testerone so … Androgen Insensitivity Syndrome affects the sexual development before the birth of the child and during puberty. Androgen insensitivity syndrome (AIS) is a rare condition that affects the development of a child's genitals and reproductive organs.